Abstract
Plasma testosterone (T), T response to hCG (3 × 1500u), estradiol (E2), basal and post-LHRH (0.1 mg/m2) LH and FSH, and serum TeBG binding capacity were determined in 50 MPH with XY karyotype aged 6 months to 20 years. 4 had mixed gonadal dysgenesis and 2 deficient T biosynthesis. In the remainder, 28 were prepubertal and 16 pubertal. In the prepubertal subjects, basal T (0.21±0.04 ng/ml) and E2 (15.08±2.32 pg/ml) were elevated (p < 0.05) and T response to hCG (2.40±0.31 ng/ml) was diminished (p < 0.02). TeBG, basal and post-LHRH LH and FSH were normal. In the pubertal subjects (10 had gynaecomastia) comparison with controls showed elevation of basal T (p < 0.001), E2 (p < 0.05), TeBG (p < 0.02), basal LH (p < 0.001) and FSH (p < 0.05) and peak FSH (p < 0.01). Elevation of T and E2 in prepubertal MPH in addition to pubertal elevation of T, E2, TeBG, LH and FSH may be characteristic of androgen unresponsiveness.
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Savage, M., Chaussain, J., Evain, D. et al. Hormonal studies in male pseudohermaphroditism (MPH). Pediatr Res 12, 152 (1978). https://doi.org/10.1203/00006450-197802000-00036
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DOI: https://doi.org/10.1203/00006450-197802000-00036