Abstract
Trephine biopsy of tetracycline labeled bone, parathyroid hormone levels and bone densitometry using photon absorptiometry were accomplished in a 14-year-old girl with 45,X karyotype who also has a craniopharyngioma. At the time of the initial studies, she was taking replacement hydrocortisone, 10mg. every morning and 5mg. at night and 150mcg. of Thyroxine daily. The cell and tissue level dynamics of bone remodelling were elevated and slightly above normal compatible with high turnover bone. In retrospect this may have been related to the slightly high thyroxine replacement dose. Following eight months of growth hormone treatment, the dynamics showed further increase in bone activity at both the haversian and endosteal-cortical surfaces. The thyroxine replacement remained constant. She grew three inches, whereas she had previously only grown ½ inch per year. The parathyroid hormone levels did not change significantly. The bone densitometry was 7 standard deviations below normal for age and sex and did not change significantly with treatment.
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Leach, D., Weiss, L. 871 BONE DYNAMICS AND MINERAL METABOLISM IN A PATIENT WITH TURNER SYNDROME AND A CRANIOPHARYNGIOMA TREATED WITH GROWTH HORMONE. Pediatr Res 12 (Suppl 4), 509 (1978). https://doi.org/10.1203/00006450-197804001-00876
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DOI: https://doi.org/10.1203/00006450-197804001-00876