Abstract
The serum cholesterol (SC) determined by single measurement in 2,421 children aged 6-18 years did not differ among those aged 6-11, decreased with ages 12-15, and increased with ages 16-18. Cholesterol in low-density lipoprotein (LDL) paralleled the SC trend (Fig. 1). The increase of SC from lower-decile to higher-decile children was due mostly to increase of the LDL fraction (Fig. 2)--a fact important in study of SC determinants, whether environmental or genetic. In search for “major genes” affecting SC, associations of marker gene distributions with quantitative differences in LDL should be sought, because relationships with LDL may be stronger than relationships with SC or with other fractions. Also, levels of LDL and high-density lipoprotein may be factors in atherogenesis and should be studied further.
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Weldman, W., Labarthe, D., Ellefson, R. et al. LIPOPROTEIN FRACTIONS IN CHILDREN WITH LOW AND HIGH TOTAL SERUM CHOLESTEROL. Pediatr Res 11, 523 (1977). https://doi.org/10.1203/00006450-197704000-00918
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DOI: https://doi.org/10.1203/00006450-197704000-00918