Abstract
Counterimmunoelectrophoresis (CIE) and Ouchterlony gel diffusion were used for the detection and titration of antibodies to staphylococcal teichoic acid (TAA) in various disease states caused by Staph. coag. positive (SC+) in infants and children. Serum samples were obtained on admission, at 2 weeks, and up to 12 weeks into the illness. TAA were found by CIE in 70% (7/10) of patients with invasive SC+ disease with bacteremia (group A), 14% (1/7) of patients with SC+ infection without bacteremia (group B), 0% (0/19) of patients with bacteremia and/or invasive infections not caused by SC+ (group C) and 0% (0/13) of non-infected, hospitalized patients and healthy children (group D). Gel diffusion was less sensitive than CIE, but was useful for titrating TAA in CIE positive sera. With successful therapy, TAA titer declined or disappeared in group A patients.
TAA serology is specific for SC+ infections, and the determination of TAA by CIE and gel diffusion may help distinguish patients with deep-seated infections associated with SC+ bacteremia from all other patient groups studied.
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Le, C., Lawin, E. TEICHOIC ACID SEROLOGY IN VARIOUS STAPHYLOCOCCAL COAGULASE POSITIVE INFECTIONS IN INFANTS AND CHILDREN. Pediatr Res 11, 502 (1977). https://doi.org/10.1203/00006450-197704000-00793
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DOI: https://doi.org/10.1203/00006450-197704000-00793