Abstract
To determine if there are age-related differences of the cardiovascular (CV) responses to dopamine (Dp), Dobutamine (Db) and isoproterenol (I), we recorded cardiac output (CO), renal blood flow (RBF), central aortic blood pressure (CAP) and heart rate (HR) in 24 anesthetized puppies 1-65 days old and 3 adult dogs during incremental infusion of Dp, Db, (2-50 μg/kg/min) and I (0.05-1 μg/kg/min).
Relatively high doses (20-50 μg/kg/min)of Dp produced a greater increase in CO and CAP in adult dogs than in puppies but RBF and HR were increased equally in both groups at all doses. In puppies, CO was reduced at low doses of Db (2-10 μg/kg/min) but increased at high doses (20-50 μg/kg/min). In adult dogs, CO was increased by all doses of Db. RBF was decreased in puppies but was increased in adult dogs by all doses of Db, but CAP and HR increased equally in both groups. There was no difference between adult dogs and puppies in their CV responses to I.
ABF, RBF, and CAP were increased more by Dp than by Db or I at all ages. HR was increased more by I than by Dp or Db. RBF and CAP were decreased from control at all doses of I.
This study demonstrates age-related differences in the response of the CV system to Dp and Db but not to I. In anesthestized canines, Dp is more effective in increasing ABF, RBF, and CAP than Db or I.
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Driscoll, D., Gillette, P., Lewis, R. et al. CARDIOVASCULAR RESPONSES OF THE NEONATAL CANINE TO DOPAMINE, DOBUTAMINE AND ISOPROTERENOL. Pediatr Res 11, 389 (1977). https://doi.org/10.1203/00006450-197704000-00117
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DOI: https://doi.org/10.1203/00006450-197704000-00117