Abstract
TPN increases survival of adults with acute renal failure and may result in faster recovery of renal function (Abel et al., NEJM, 288:695, 1973). To study the latter possibility, a model of transient unilateral renal ischemia was used to measure reparative growth in the ischemic kidney (IK) and compensatory growth in the contralateral kidney (CK). 60 hours after ischemia, weight (wt), protein (Pr) and DNA were determined in both kidneys of 170-182 gm rsts receiving either TPN (318 Cal/kd/d; n=6), or isocaloric amounts of glucose IV (n=6). Controls (n=13) were chow-fed unoperated rats.
The data reveal that the mass of CK is maintained with TPN while a loss occurs with glucose alone. Reparative growth of IK of animals given TPN is also greater; both Pr content and Pr concentration are significantly greater with TPN (p<.001). Lack of significant differences in DNA suggests that the reparative growth is hypertrophic. These findings support the suggestion that TPN may result in faster recovery of renal function. If so, a regimen containing amino acids should be more beneficial in treating patients with acute renal failure than glucose alone.
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Simpson, E., Brasel, J. & Heird, W. EFFECT OF AMINO ACIDS AND GLUCOSE (TPN) ON RECOVERY FROM ACUTE RENAL ISCHEMIA. Pediatr Res 11, 558 (1977). https://doi.org/10.1203/00006450-197704000-01129
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DOI: https://doi.org/10.1203/00006450-197704000-01129