Abstract
Six patients with idiopathic, minimal change nephrotic syndrome treated previously with Prednisone without long-term success (4 patients steroid dependent or frequent relapser, 2 steroid resistant) received Indomethacin for five weeks. The drug was given in a dose of 1 mg/kg/day during the first week and at 2 mg/kg/day therafter. Prednisone was tapered to maintenance dose (equivalent to 20 mg Hydrocortisone/m2/day) prior to the initiation of Indomethacin therapy. Urine protein excretion (Up-g/day) was measured serially before (B) and after (A) treatment with indomethacin.
Indomethacin does not seem to reduce proteinuria in patients with idiopathic, minimal change nephrotic syndrome at the doaaga of 2 mg/kg/day.
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Garin, E., Fennell, R., Williams, R. et al. INDOMETHACIN TREATMENT OF IDIOPATHIC, MINIMAL CHANGE NEPHROTIC SYNDROME. Pediatr Res 11, 550 (1977). https://doi.org/10.1203/00006450-197704000-01083
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DOI: https://doi.org/10.1203/00006450-197704000-01083