Abstract
Sleep state and an altered CO2 response have been implicated in the pathophyeiology of idiopathic apnea of prematurity and the Sudden Infant Death Syndrome. In order to examine the effect of sleep on CO2 sensitivity, the steady state ventilatory response to inhaled CO2 was determined in gestationally timed Macaca nemestrina at 7 and 21 days of age. Tidal volume (VT) and respiratory frequency (f) were measured in premature (gestational age = 143-150 days) and term (gestational age = 165-169 days) animals in the awake (Aw), REM and NREM states following CO2 inhalation. Sleep state was determined from simultaneous recordings of sleep electroencephalograms. Data presented is the slope of the ventilatory response, ±SE, cc/Kg.min mmHg PICO2 on day 7.
There were no differences among the slopes of the CO2 response curves plotted against PICO2 or PaCO2 in the Aw, REM or NREM states in premature or term animals at postnatal ages 1 or 7 days. During CO2 breathing a large increase in VT and a small increase in f was observed in each state in both premature and term animals at each postnatal age. There were no differences in the %ΔVT/Kg. mmHg PICO2 or %Δf/Kg.mmHg PICO2 in REM compared to NREM sleep. Sleep state does not influence the CO2 sensitivity of the premature or term monkey between 1 and 3 weeks of age.
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Guthrie, R., Standaert, T., Hodson, W. et al. EFFECTS OF SLEEP STATE ON THE VENTILATORY RESPONSE TO INHALED CO2 IN THE NEONATAL PRIMATE. Pediatr Res 11, 534 (1977). https://doi.org/10.1203/00006450-197704000-00984
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DOI: https://doi.org/10.1203/00006450-197704000-00984