Abstract
Parameters of serum free fatty acid /FFA/ metabolism: pool size half time disappearance rate, turnover time and absolute turnover rate and the influx of serum FFA into the glycerides of brown adipose tissue /BAT/ and the pathway of triglyceride /TG/ synthesis in BAT /alfa-glycerophosphate versus monoglyceride pathway/ were examined after intravenous injection of 14C-1-palmitate in newborn rabbits /1/. In the thermoneutral environment of 35°C /Ta=35°C/ the turnover rate of serum FFA was 10,20 μmol/min and its flux into the glyoerides of BAT 0,367 μmol/min. Cold exposure /Ta=20°C/ caused a decrease to 5,84 umol/min and 0,207 μmol/min respectively. Specific radioactivities showed uniform labelling of TG of BAT with the injected 14C-FA in all three positions, indicating that both under basal conditions /Ta=35°C/ and under cold induced thermogenesis /Ta=20°C/ triglyceride synthesis in BAT ran through the alfa -glycerophosphate pathway. /1/. Schenk, H., Heim, T., Mende, T., Varga, F., Goetze, E.:Europ.J.Biochem. 1975. /In press/.
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Schenk, H., Heim, T., Mende, T. et al. EFFECT OF COLD INDUCED THERMOGENESIS ON FREE FATTY ACID METABOLISM AND TRIGLYCERIDE SYNTHESIS OF BROWN ADIPOSE TISSUE IN THE NEWBORN RABBIT. Pediatr Res 10, 558 (1976). https://doi.org/10.1203/00006450-197605000-00026
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DOI: https://doi.org/10.1203/00006450-197605000-00026