Abstract
Effects of a 24 hour fast were studied in 22 obese children aged 7 to 14 years and in 8 controls.Mean blood glucose /BG/ during fast dropped more in controls /0.90 to 0.50g/l/ than in obese /0.92 to 0.63g/l/. Plasma cortisol changes were similar in the 2 groups. FPA increased /p 0.0l/ in the 2 groups, but the 24 hour mean level was higher in controls /4.omEq/l/than in obese /2.06mEq/l/. At the end of the fast, a ketonuria was present in all children. Serum alanine dropped similary in obese /28 to 24uM%/ and in controls /30 to 22uM%/. All obese exhibited at the end of the fast a significant rise /p 0.00l/ of branched chain aminoacids, not observed in controls. Responses to g glucagon /0.03mg/kg I.M./ were studied before and after fast. At time, O, BG response was higher and more prolonged in obese in spite of hyperinsulinism. At time 24 hour, the response to gluoagon was strongly decreased in controls /0.50 to 0.74g/l for BG, 8 to 35 uU/ml for insulin/ while in obese BG raised from 0.63 to 1.06g/l and insulin from 25 to 88uU/ml. Thus 24 hour fast evidence in obese children 1/a sustained hyperinsulinism 2/concomitant criteria of hypoinsulinism suggesting a peripheralresistance to insulin 3/a limited lipolysis.
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Chaussain, J., Georges, P., Olive, G. et al. EFFECTS OF A 24 HOUR FAST IN OBESE CHILDREN. Pediatr Res 10, 556 (1976). https://doi.org/10.1203/00006450-197605000-00012
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DOI: https://doi.org/10.1203/00006450-197605000-00012