Abstract
Extract: Rat fetal livers were homogenized and incubated for up to 3 hr in Eagle's medium. Both phosphoenolpyruvate carboxykinase (PEPK) and tyrosine transaminase (TTA) activities in the high speed supernatant increased 5-fold and 10-fold, respectively, during incubation. Neither cycloheximide nor actinomycin D inhibited this rise in activity. Inasmuch as no change in activity during incubation was found in the whole homogenate, it is concluded that a redistribution of the enzyme occurs between cell fractions
Speculation: It is suggested that the initial increase in TTA and PEPK activities in the liver very soon after birth may be due to release of preformed enzyme from polysomes and that this triggers a sequence of events leading to new enzyme synthesis
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Kirby, L., Hahn, P. Changes in Tyrosine Transaminase and Phosphoenolpyruvate Kinase Activities during Short Term Incubation of Fetal Liver. Pediatr Res 10, 243–245 (1976). https://doi.org/10.1203/00006450-197604000-00009
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DOI: https://doi.org/10.1203/00006450-197604000-00009