Abstract
PRL has been determined before and after TRH IV (200 ug/m2) in 23 children (11 ♀/12 ♂) with craniopharyngioma using reagents provided by the NIAMDD, Bethesda USA. As controls served 10 endocrinologically healthy children (4♀/6♂), aged 4-16 yrs, who had TRH tests for other reasons. 13 patients, aged 1-13 yrs, have been studied before surgery, 10 of them and 10 additional patients, aged 1-20 yrs, after surgery.
Assuming that PRL secretion is controlled by PIF (PRL inhibiting factor), elevated PRL levels as seen before and after surgery would indicate hypothalamic disorder or disruption of the hypothalamo-pituitary axis. PRL deficiency, observed only after surgery, would reflect pituitary damage.
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Illig, R., Torresani, T., Zachmann, M. et al. 67: PLASMA PROLACTIN (PRL) BEFORE AND AFTER TRH IN 23 CHILDREN WITH CRANIOPHARYNGIOMA. Pediatr Res 10, 882 (1976). https://doi.org/10.1203/00006450-197610000-00062
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DOI: https://doi.org/10.1203/00006450-197610000-00062