Abstract
Heritability of stature was slightly higher in males than in females and the findings in patients with sex chromosome disorders were very similar. The genetic pattern was largely lost in Down syndrome which implicates the autosomes in the determination of normal adult stature.
The findings in idiopathic precocious puberty and CAH indicate a loss of genetic determination except in girls with idiopathic precocious puberty. This may be a reflection of the fact that idiopathic precocious puberty in boys and CAH are pathological conditions; most girls with precocious puberty are extreme variant or normal
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Brook, C., Gasser, T., Werder, E. et al. 58: Height correlations between parents and mature offspring in normal subjects and in subjects with Turner, Klinefelter and Down syndromes, idiopathic precocious puberty and congenital adrenal hyperplasia. Pediatr Res 10, 881 (1976). https://doi.org/10.1203/00006450-197610000-00055
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DOI: https://doi.org/10.1203/00006450-197610000-00055