Abstract
HPr has been measured by radioimmunoassay (RIA) with FRIESEN materials. TRH RIA was performed by Dr Oliver. The mean (ng±SD/ml) HPr in paired maternal and cord plasma (n=13) was respectively 77.5±45.5 and 91.2±21.2. Mean HPr in plasma collected during the first six hours of life in 16 individual newborns was 144.7±63.9. Longitudinal study of 3 newborns indicates a small rise of HPr occurs between 30 min and 6 hrs. Measurement of plasma TRH in paired mothers and newborn gives the following results (pg/ml and range): mother 15.0 (7–29), cord= 41.8 (27–47), 20′ = 39.6 (33–49), 40′ = 44 (39–49), A separate study indicated no differences for plasma TRH in the cord between venous and arterial blood (n=2). In conclusion: 1) There is no sharp rise of HPr during the first hours of life as has been shown for TSH. 2) High plasma TRH in the newborn is probably responsible for the acute stimulation of pituitary thyroid axis. As it has been demonstrated previously that cord TSH is not high it can be postulated that TRH is ineffective in utero to stimulate thyrotroph cells.
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Czernichow, P., Oliver, C. & Friedman, R. TRH AND PROLACTIN (HPr) IN PLASMA OF NEWBORNS DURING THE FIRST HOURS OF LIFE. Pediatr Res 9, 668 (1975). https://doi.org/10.1203/00006450-197508000-00020
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DOI: https://doi.org/10.1203/00006450-197508000-00020