Abstract
Screening programs for hypothyroidism are highly wanted and technically possible. In Norway serum is used for PKU screening. The T4 RIA of Dunn and Foster was modified for 10 ul serum. The stability of T4 during transport is, however, low. Standing at room temperature there is a 5–10 % decay per 24 hours. Another problem is T4 variations during inter current diseases. In premature infants without RDS T4 was slightly lower /8.9 ul/100 ml/ than in fullterm /9.9/ while prematures with RDS have low mean levels /4.5/ and some definite hypothyroid values. In some prematures the levels were within normal range before the distress started, suggesting that this is an adaptive process and not related primarily to the cause of RDS as previously suggested. It is important to define conditions with low T4 levels in newborn before large scale screening is introduced.
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Lukas, W., Vidnes, J. & Halvorsen, S. NEONATAL SCREENING FOR HYPOTHYROIDISM WITH T4 RIA. Pediatr Res 9, 867 (1975). https://doi.org/10.1203/00006450-197511000-00094
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DOI: https://doi.org/10.1203/00006450-197511000-00094