Abstract
Five children with growth failure undergoing routine investigation by the arginine loading test, a normal adult, a petient with cystinuria /Type II/II/and a heterozygote of cystinuria/Type II/served as subjects. Serial blood samples and quantitative timed urine collections were obtained before and after i.v. infusion of 0.5mg/kg body weight L-arginine in buffered saline. Plasma and urinary amino acids were measured by automated column chromatography. The clearencea of amino acids and, on the basis of creatinine clearances, the filtered loads and percentage reabsorptions were calculated. Arginine infusion led to vast increases in the filtered load of arginine, minor increase in the filtered load of ornithine, minimal increases in that of lysine, but the filtered load of cystine was not changed. Following the arginine infusion the tubular reabsorption of cystine, lysine, ornithine and arginine was markedly reduced. In the patient with cystinuria marked tubular secretion of cystine was observed. We conclude that under physiological and certain pathological conditions cystine transport is competitively inhibited in vivo by the dibasic amino acid arginine.
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Sass-kortsak, A., Cole, D. & Graham, S. EFFECT OF ARGININE LOADING ON RENAL TUBULAR REABSORPTION OF CYSTINE AND LYSINE. Pediatr Res 9, 865 (1975). https://doi.org/10.1203/00006450-197511000-00082
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DOI: https://doi.org/10.1203/00006450-197511000-00082