Abstract
Extract: Four protein dietary groups of rats were used in this study, namely: 27% casein diet fed throughout gestation and lactation (group C-C); 27% gestation, 10% lactation (group C-D); 10% gestation, 27% lactation (group D-C); 10% throughout gestation and lactation (group D-D). Mean body weight of group D-D at weaning was 19 g compared with 59 g for group C-C.
The specific activity of Na+-K+-ATPase in isolated synaptosomes from cerebral and cerebellar tissues increases throughout the lactation period. At 1 and 7 days of age no differences in Na+-K+-ATPase activity are noted in the brain regions of Groups C-C and D-D. At 14 and 21 days, however, the specific Na+-K+-ATPase activity was significantly reduced in isolated synaptosomes from both brain regions of the protein-deprived group. ATPase activity in cerebellar synaptosomes from dietary exchange groups (C-D and D-C) developed to the same extent as that of the control group (C-C) after 21 days of lactation. ATPase activity in the cerebral synaptosomes of the dietary exchange group (C-D) did not develop to the same extent as that in the control group (C-C) and the other dietary exchange group (D-C).
Speculation: Na+-K+-activated ATPase plays a fundamental role in synaptic transmission and possibly in transport of neurotransmitters. Synaptosomal ATPase activity increased rapidly in the neonatal rat brain. Inadequate protein nutrition during the fetal and neonatal development period could retard enzyme expression and alter behavior patterns.
Rehabilitative value of administering augmented diets would depend upon the neonatal age and the region of the brain examined. Cerebellar hyperplasia ceases before cerebral hyperplasia; therefore, selected lesions and behavior abnormalities may develop.
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Kissane, J., Hawrylewicz, E. Development of Na+-K+-ATPase in Neonatal Rat Brain Synaptosomes after Perinatal Protein Malnutrition. Pediatr Res 9, 146–150 (1975). https://doi.org/10.1203/00006450-197503000-00008
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DOI: https://doi.org/10.1203/00006450-197503000-00008
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