Abstract
We have previously reported on a group of children and adolescents with constitutional short stature (CSS), lean body, retarded skeletal age, and low insulin response to arginine and glucose. It was hypothesized that the low insulin output was the cause of the growth failure. For further clarification the following investigation was performed in some of these children: 1) I.V. Glucagon test. 2) Plasma Glucagon determination during i.v. Arginine, 3) Dietary investigation in the above children and children with CSS, lean body, and normal insulin.
The results obtained were as follows; (1) 7 out of 8 children showed a normal insulin peak at 2 minutes during the i.v. Glucagon test (range;53 uU/ml-180 uU/ml). (2) 22 children showed a relatively low glucagon response during i.v. Arginine test (Δ 194±25 Pg/Ml in the patients vs.Δ268±32 Pg/ml in controls). (3) The total caloric intake of the children of group a) was 3021; 55% as carbohydrates. In group b) 2996; 54% as carbohydrates.
The absence of glucose intolerance may be attributed to an intact “rapid” insulin pool in the Beta cell, and a relatively low glucagon response. The low insulin and leanness of body are not related to the caloric intake.
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Karp, M., Laron, Z., Josefsberg, Z. et al. METABOLIC STUDIES IN CHILDREN WITH CONSTITUTIONAL SHORT STATURE. Pediatr Res 9, 689 (1975). https://doi.org/10.1203/00006450-197508000-00132
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DOI: https://doi.org/10.1203/00006450-197508000-00132