Abstract
Spontaneous GH- and LH-secretion during the night was measured by RIA in 27 children and adolescents with normal (n=9) or disturbed pubertal development (precoc. pub., pit. tum., Turner's S.). Incidence and correlation of episodic bursts of these two hormones during sleep and wakefulness were evaluated. Sleep was recorded by observation, blood was drawn every 30 min. from 7 p.m. to 8 a.m. In the 9 controls a total of 29 episodes each of GH- and LH-secretion was recorded. 5 of these GH- and 3 of the LH-bursts occurred following sleep onset (within 60 min.), 19 GH- and 20 LH-peaks during the entire sleepperiod. 14 out of 29 coincided (increase simultaneously or up to 30 min. apart), only 2 of these following the onset of sleep. In the patients with abnormal puberty (n=18), 55 GH- and 38 LH-episodes were found, 7 GH- and 2 LH-peaks followed sleep onset. The rate of coincidence of 15 (total period of observation) and 1 (sleep onset) respectively is proportionally smaller than for the normal adolescents. In none of the 27 a coincidence of all secretory episodes was recorded. If no correlation between GH and LH existed, about 20% of the episodes (calculated from the relative time they cover) should coincide by chance, but 40% did. Nevertheless, these data do not yet seem to justify the assumption of a common regulatory mechanism of GH- and LH-secretion in puberty.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Zabransky, S., Mühlendahl, K., Weber, B. et al. IS THERE A CORRELATION BETWEEN GH AND LH SECRETION DURING THE NIGHT?. Pediatr Res 9, 686 (1975). https://doi.org/10.1203/00006450-197508000-00117
Issue Date:
DOI: https://doi.org/10.1203/00006450-197508000-00117