Abstract
We have previously reported our experience in treating children with sex hormones. A difficulty of that preliminary study was the inaccuracy of bone age (BA) estimation (Greulich and Pyle) and of adult height prediction (Bayley and Pinneau). BA was reassessed in an extended series of 40 girls using the Tanner-Whitehouse II RUS technique and the new regression equations of Tanner for prediction of adult height. All girls were in puberty at start of treatment (BA > 12). They were divided into 3 BA-groups (12.1–13, 13.1–14, 14.1–15) and received ethinylestradiol 0.3 mg daily and norethisterone for 5–7 days every 4th week. The mean reduction of adult height was 4.6 ± 2.4 cm, slightly more (5.8) in the youngest and somewhat less (4.5) In the oldest BA-group. BA-velocity during the whole treatment period was 1.5 ± 0.5 yrs per yr in the youngest and 1.1 ± 0.4 yrs/yr in the oldest BA-group. The individual variation, however, was large in all groups. Posttherapeutic amenorrhea of 0.2−0.5 yrs occurred in only 7 patients.
This Improved method of analysis confirms the effectiveness of sex hormone treatment in tall girls.
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Zachmann, M., Mürset, G., Ferrandez, A. et al. EXCESSIVELY TALL STATURE IN GIRLS. FURTHER EXPERIENCE WITH SEX HORMONE TREATMENT IN HIGH DOSES. Pediatr Res 9, 685 (1975). https://doi.org/10.1203/00006450-197508000-00112
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DOI: https://doi.org/10.1203/00006450-197508000-00112