Abstract
In some patients with ketotic hypoglycemia a reduced urinary output of catecholamines has been reported. Emplying a double isotope derivative technique (Clin.Sci.1973, 45:163) plasma adrenaline and noradrenaline were determined in six children with ketotic hypoglycemia. One of the patients had extensive bilateral adrenal calcifications. Adrenal cortical insufficiency was excluded.
The plasma adrenaline values (mean value, ng/ml) before - during hypoglycemia were: (A) in patients without adrenal calcifications 0.05−0.10, (B) in one patient with adrenal calcification 0.01−0.04, (c) in healthy children (n=3) 0.22–1.33, (D) in healthy adults (n=5) 0.09−0.69. The plasma noradrenaline changed insignificantly in patients and controls.
Estimated from blood glucose level during hypoglycemia the plasma adrenaline was only four per cent of the expected values.
These preliminary results seem to indicate that in patients with ketotic hypoglycemia the immediate plasma adrenaline response during hypoglycemia is greatly reduced in patients with as well as without adrenal calcifications.
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Jacobsen, B., Kastrup, K. & Christenser, N. PLASMA ADRENALINE RESPONSE IN KETOTIC HYPOGLYCEMIA. INVESTIGATIONS IN PATIENTS WITH OR WITHOUT ADRENAL CALCIFICATIONS. Pediatr Res 9, 685 (1975). https://doi.org/10.1203/00006450-197508000-00107
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DOI: https://doi.org/10.1203/00006450-197508000-00107