Abstract
Somatomedin (SM) was determined in cord blood and maternal blood with the chick embryo assay. The ratio cord blood/maternal blood was around 0.90. Synchronous variations between the paired samples could be demonstrated suggesting a placental transfer. In prematures low values around 0.30 units SM was found in the first days of life, within 6 days the values were in the range for normal infants - 6 months of age. In mature infants initial values about 0.70 units SM was found to be within normal range after 6 days of life. Growth hormone excretion in the urine was determined also in prematures. In prematures very high excretion was found in the first 3 days of life i.e. more than 1000 ng/100 ml. After 6 days excretion of 100 - 1000 ng/100 ml was found. In matures the initial excretion in the range of 500 ng/lOOml decreased to less than 100 ng/100 ml in one week. The high excretion in prematures is related to impaired renal function but also represnets increased production. It is suggested that the increased production of growth hormone in the first days of life is related to generation of SM in the newborn.
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Kastrup, K., Andersen, H. STUDIES ON SOMATOMEDIN IN NEWBORN AND ITS RELATIONSHIP TO THE EXCRETION OF GROWTH HORMONE IN URINE. Pediatr Res 9, 683 (1975). https://doi.org/10.1203/00006450-197508000-00098
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DOI: https://doi.org/10.1203/00006450-197508000-00098