Abstract
In order to assess the mineralocorticoid adjustment, plasma renin activity (PRA), PA and 17-OH progesterone (17 OHP) were measured by radioimmunoassay in 15 CAH children aged 5 to 16 years on controled sodium diet, treated exclusively with oral hydrocortisone (F), 20-25 mg/m2/day. Mean baseline PA was above control values of 13.0 ± 7.8 ng/100 ml in 5 non salt losers, group I, PA = 26.4 ± 6.7 ng/100 ml, p < 0.01, while PA = 20.3 ± 6.8 ng/100 ml in 10 salt losers, group II (NS with controls). However, among salt losers, we found 4 high PA basal values ranging from 36 to 66 ng/100 ml. Under ACTH stimulation (synacthen ®0.25 mg i.m.), PA increased significantly in Group I 30 min. post ACTH, (PA = 44.0 ± 8.7, p < 0.01) and was unchanged in Group II, PA = 20.9 ± 6.4 ng/100 ml, NS with controls (34.9 ± 7.8 ng/100 ml). Elevated PRA in G.I. (3/5 cases) and in G.II (5/10 cases) was associated with increased basal PA. A positive correlation was found between PA and 17-OHP (r = 0.72, p < 0.01). However, high PA, PRA and 17 OHP returned to normal levels in 4 salt losers given 9α fluoro-hydrocortisone. In conclusion, F alone adequate for normal growth, was unable to suppress hyperaldosteronism in patients of both groups.
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Limal, J., Eayard, F. & Rappaport, R. PLASMA ALDOSTERONE (PA) AND EFFECT OF ACTH IN CONGENITAL ADRENAL HYPERPLASIA, 21-OH DEFICIENCY (CAH). Pediatr Res 9, 681 (1975). https://doi.org/10.1203/00006450-197508000-00086
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DOI: https://doi.org/10.1203/00006450-197508000-00086
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