Abstract
PA was estimated by radioimmunoassay. Twenty normal subjects aged 5 to 30 years, placed in the supine position, for 2 hours sampled between 8 and 10 a.m., during a normal sodium intake had a mean PA value of 20.6 ± 2.4 (SEM) pg/ml (basal levels). The increase in PA after IM injection of ∝ 1–24 ACTH (250 μg) was 500 to 2000 % (9 subjects) and after five days of low sodium intake (LSI) it was 457 to 1220 % (5 subjects). In 12 infants aged 1 to 12 months, the mean basal PA was 102 pg/ml (range 19 to 171 pg/ml). Among the 20 children with congenital adrenal hyperplasia, 4 salt loosers were studied before any treatment during the first month of life, while they were suffering from an acute salt depletion. Their PA were lower than 50 pg/ml. Sixteen 2 to 9 year old patients never (had clinical symptoms of salt depletion. While 8 of these were not under treatment, basal PA were elevated (40 to 320 pg/ml). The LSI and the ACTH injection induced variable but limited increases in PA. Since the biosynthesis of Aldosterone appears to be limited, these patients may be considered potential salt loosers. When treated with cortisol, the PA levels decreased and a positive correlation ( p < 0.001) between PA and 17 Hydroxyprogesterone, levels was observed. In 13 of the 17 children with Addison's Disease, PA was lower than 15 pg/ml. Four other patients exhibited normal basal levels and the increases in PA during LSI were 300 to 1100 %, with normal sodium balances. A deficiency progressively affecting diverse adrenocortical functions is discussed.
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Raux, M., Phan-Huu-Trung, M., Baron, M. et al. PLASMA ALDOSTERONE (PA) IN CHILDREN WITH ADRENAL INSUFFICIENCY. Pediatr Res 9, 681 (1975). https://doi.org/10.1203/00006450-197508000-00085
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DOI: https://doi.org/10.1203/00006450-197508000-00085
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