Abstract
The binding properties of prostaglandin PGE and ACTH, and their action on adenylate cyclase activity (AC) have studied in 12 hormone producing tumors of the human adrenal cortex and compared with those found in the same type of subcellular preparation (20 000 xg) from normal human adrenal glands.
A specific binding of PGE and a stimulation of AC by this hormone and by NaF was obtained in all cases. A specific binding of 125I-ACTH was also observed in all cases, but ACTH only stimulated AC in six cases. In the other six cases where AC was insensitive to ACTH, the steroidogenesis was not stimulated “ in vivo ” by this hormone. However these tumors bound specifically 125I-ACTH1–24 and 125I-ACTH11–24, the KD being similar for both peptides but ten times lower than the one found in normal adrenal cortex for 125I-ACTH1–24. This results strongly suggests the possibility of a modification or a loss of the receptor site which binds the N-terminal sequence (1–10) of ACTH known as the biologically active part of the molecule.
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Saez, J., Dazord, A. & Audi, L. ACTH AND PROSTAGLANDINS, RECEPTORS IN HUMAN ADRENOCORTICAL TUMORS. Pediatr Res 9, 681 (1975). https://doi.org/10.1203/00006450-197508000-00083
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DOI: https://doi.org/10.1203/00006450-197508000-00083