Abstract
Fetal and adult HGH extract from human pituitáries as well as plasma from premature and fullterm newborns and children were submitted to chromatography on Sephadex G-75 and the IR-HGH in the elution fractions was determined quantitatively by radio-immunoassay.
Three fractions of IR-HGH could be differentiated according to the elution pattern: “big-big”, “big” and “little” IR-HGH.
In fetal pituitary extract only “big-big” and “little” IR-HGH were found whereas in adult pituitary extract all three forms of IR-HGH were present. In the plasma samples studied no “big-big” form was found; only “big” and “little” IR-HGH appeared. In addition, plasma samples of premature newborns had a smaller proportion of the “big” IR-HGH than did those of the fullterm newborns and older children. It is suggested that the “big” forms of the IR-HGH are pro-hormones.
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Eshet, R., Assa, S. & Laron, Z. HETEROGENEITY OF PITUITARY AND ENDOGENOUS PLASMA HGH FROM FETUSES, PREMATURES AND FULL-TERM NEW BORNS. Pediatr Res 9, 680 (1975). https://doi.org/10.1203/00006450-197508000-00082
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DOI: https://doi.org/10.1203/00006450-197508000-00082