Abstract
4 patients (If, 3m, 15–18 yrs) presented with clinical CS. Urinary 170HC were increased (16.9 mg/24 h), but classic criteria excluded CS (2 mg dexamethasone suppression, normal plasma F and diurnal rhythm). Urinary THE, THF-allo THF and cortolone determined by gas chromatography on capillary column were slightly increased (sum = 11.4 mg/m2/24h), but β-cortolone was normal. Free urinary F was increased (206 μg/m2/24h). In 1 case, the metabolism of exogenous F and E was studied. i.v.F and p.o.E resulted in increased THF and THE respectively, as in controls. The pattern after p.o.F, however, was different : THE and THF remained low, but β-cortolone increased, while THF increased in controls. Phenobarbital reduced all steroids in the patient. In 3 cases, serum LDH was found to be high, suggesting impaired liver function. It is concluded that CS in these cases might be due not to increased F production, but to altered F catabolism, possibly in the liver.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Zachmann, M., Zagalak, M., Stolecke, H. et al. UNUSUAL TYPE OF CUSHING'S SYNDROME (CS) IN ADOLESCENTS. Pediatr Res 9, 676 (1975). https://doi.org/10.1203/00006450-197508000-00072
Issue Date:
DOI: https://doi.org/10.1203/00006450-197508000-00072