Abstract
TRH (thyrotrophin releasing hormone) induced TSH (thyroid stimulating hormone) release has been studied in 11 patients with active gluten-sensitive enteropathv and in 21 normal children. Blood samples were taken before and 20, 40 and 60 min after intravenous administration of 200 μg of synthetic TRH. The data reported are means ± 1 S.E.M. In normal children basal plasma TSH of 5.9±1.5 μU/ml increasesto 32.6±3.5 μU/ml at 20 min and decreases to 21.3±3.0 μU/ml at 60 min. In 9 out of the 11 coeliac patients an exaggerated response is observed. Basal plasma TSH level of 6.3±1.3 μU/ml is not significantly different from the value observed in normal children. But plasma levels recorded 20 min (52.1±5.8 μU/ml) and 60 min (51.7±7.5 μU/ml) after the administration of TRH are significantly higher than in normal children (at 20 min p = 0,01−0.001; at 60 min p<0.001).
These data give additional evidence of a dysfunction in the hypothalamo-hypophyseal system in coeliac disease (Helv.paediat. Acta 28: 349, 1973), It is not clear whether it is due to malnutrition, to some direct action of gluten-peptides or to other factors.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Vanderschueren-Lodeweyckx, M., Eggermont, E., Cornette, C. et al. TRH INDUCED TSH RELEASE IN COELIAC DISEASE. Pediatr Res 9, 675 (1975). https://doi.org/10.1203/00006450-197508000-00067
Issue Date:
DOI: https://doi.org/10.1203/00006450-197508000-00067