Abstract
Urine from the listed groups of patients and from normal controls were fractionated by protein precipitation and Sephadex gel filtration. The chromatograms were different for the three groups of patients, and they differed from that of the normal controls. Fractions with mol.wt. in the range of 1000 were observed to be metabolic active in mice. Daily injections to groups of animals were given over three weeks. The fraction from patients with generalized lipodystrophy produced persistent lipodystrophy in infantile animals, and lipoatrophic diabetes in adult animals. The corresponding fraction from the metabolic obese patients induced obesity, and the mean body weight of the mice increased from 36g to 70g. The obesity persisted for four months. The fraction from the patients with anorexia nerv osa had an anorexogenic effect that persisted for four weeks. The body weight decreased 15% for albino and 30% for obese yellow mice. The amino acid compositions of the urinary fractions was similar to that of thalamic agents. The active factors are supposed to be hypothalamic.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Trygstad, O., Foss, I. METABOLIC ACTIVE PEPTIDES ISOLATED FROM THE URINE FROM PATIENTS WITH CONGENITAL GENERALIZED LIPODYSTROPHY, “METABOLIC” OBESITY, AND ANOREXIA NEVROSA. Pediatr Res 9, 675 (1975). https://doi.org/10.1203/00006450-197508000-00066
Issue Date:
DOI: https://doi.org/10.1203/00006450-197508000-00066