Abstract
Plasma levels of 17 Hydroxyprogesterone (17 OHP) and Progesterone (P) were measured by specific radioimmunoassays in 76 newborns and infants (36 boys, 40 girls), for 17 OHP and 42 newborns and infants (16 boys and 26 girls) for P. Cord blood values of 17 OHP and P were also evaluated in, respectively, 25 and 20 cases. 17 OHP mean level (ng/ml ± SEM) in cord blood was 45.91±3.45, in the newborns during the first 12 hrs. 7.55±o.59 (n=14), from 12 to 24 hrs. 3.60±0.72 (n=8). After the 24th hr., up to 1 month, 17 OHP remains in plateau at 1.31±0.10 (n=33). After 1 month there is a decrease of 17 OHP which is, at 6 months, in the prepubertal range (0.24±0.14, n=7).
P mean level (ng/ml±SEM) in cord blood was 413.20±39.76, in the newborns during the first 12 hrs. 32.23±5.23 (n=10), from 12 to 24 hrs. 11.56±1.41 (n=ll), by the 6th day of life P was in the prepubertal range : 0.29±0.06 (n=13).
The data presented, namely 1-sharp decrease of P, 2-first month plateau of 17 OHP, 3-absence of any sex difference, suggest, for 17 OHP, an adrenal contribution.
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Toublanc, J., Tea, N., Roger, M. et al. PLASMA 17 HYDROXYPROGESTERONE AND PROGESTERONE IN NORMAL NEWBORNS AND INFANTS. Pediatr Res 9, 675 (1975). https://doi.org/10.1203/00006450-197508000-00065
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DOI: https://doi.org/10.1203/00006450-197508000-00065