Abstract
Increased levels of plasma growth hormone (GH) represent a characteristic feature of diencephalic syndrome (DS) in childhood and may in part be responsible for extreme emaciation and loss of subcutaneous tissue. Somatostatin and CB 154 were shown to lower GH in acromegaly. Both substances were applied to a 3 1/2 yr old girl with DS who was unsuccessfully irradiated for a spongioblastoma of the 3rd ventricle at 1 1/2 yr of age. Somatostatin following arginine infusion or during sleep lowered GH levels immediately with a T 1/2 of 17 and 14 minutes respectively. This gives evidence of GH hypersecretion instead of impaired clearance in DS. The action of CD 154 is more protracted and doses of 4 to 10 mg daily are effective in adults. The patient received 3 mg CB 154 daily and preliminary results indicated a reduction of GH basal levels to about 30 per cent of pretreatment values. CB 154 may have favourable therapeutic effects in DS by preventing metabolic changes due to GH hypersecretion.
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Stubbe, P., Lenard, G. ACTION OF SOMATOSTATIN AND CB 154 IN THE DIENCEPHALIC SYNDROME. Pediatr Res 9, 675 (1975). https://doi.org/10.1203/00006450-197508000-00062
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DOI: https://doi.org/10.1203/00006450-197508000-00062