Abstract
Reports of damaging effect of cyclophosphamide on the germinal epithelium led us to study as whether the endocrine function may be also involved in cyclophosphamide induced side effects. 5 boys aged 9–14 years suffering from nephrotic syndrome unresponsive to steroid therapy were treated for 6–9 weeks with cyclophosphamide 2.5–3.0 mg/kg. Immediately after the end of the drugs period and a second time 13 till 28 months later they were examined by a stimulation test with HCG, using a single injection of 5000 IE/m2 body surface i.m. Basal and 1, 3 and 5 days after HCG 24 hrs urine samples as well as plasma samples (at 9 a.m.) were analyzed for pregnanetriol (P3OH) and for testosterone respectively. P3OH was determined by GLC, T by RIA.
In the 2nd series urinary P3OH increment related to bone age was sufficient in 4 patients, but in 3 cases with a tendency to decrease while compared with the values immediately after the drugs period. Plasma T-values were normal under basal conditions. After HCG 2 patients increased their T-values as so far to be expected for a normal reaction, the 3 others showed a sluggish response only. From our results we suppose that cyclophosphamide therapy may involve a risk of a damaging effect also on the endocrine part of testicular function.
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Stolecke, H., Olbing, H. & Bachmann, HJ. TESTICULAR ENDOCRINE FUNCTION IN PATIENTS TREATED WITH CYCLOPHOSPHAMIDE FOR NEPHROTIC SYNDROME. Pediatr Res 9, 674 (1975). https://doi.org/10.1203/00006450-197508000-00061
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DOI: https://doi.org/10.1203/00006450-197508000-00061