Abstract
In a boy, who got the nephrotic syndrome at the age of 4 years, growth and development were followed for 20 years. During this time glomerular function remained adequate. Initially, height was 101,5 cm (−0.8 SDS). During daily administration of prednisone in a dosage between 0.2 and 0.6 mg/kg/day, growth and development became retarded until - at the age of 15 years - height was 138.0 cm (−3.5 SDS) and S.A. (TANNER and WHITEHOUSE II) was 8 years. From that time prednisone was given every other day or 3 times per week in a dosage which slowly decreased from 2 to 1 mg/kg/week. Growth rate increased gradually from 1 cm/year at the age of 14 years until 8 cm/year at the age of 19 years, whilst the difference between C.A. and S.A. slowly decreased. Puberty began at the age of 17 years. At the age of 24 years height was 171.5 cm (−1.0 SDS) and S.A. was 18.0 years. Noteworthy features were: 1) Anachronism between the RUS- and CB-scores for S.A. amounting to 1.6 – 3.0 years during most of the time; and 2) a predicted adult height (TANNER et al., 1975) which was too low, the difference with achieved adult height being larger with increasing discrepancy between C.A. and S.A.
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Steendijk, R. REMARKABLE CATCH-UP GROWTH IN A BOY WITH THE NEPHROTIC SYNDROME, TREATED WITH PREDNISONE. Pediatr Res 9, 674 (1975). https://doi.org/10.1203/00006450-197508000-00060
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DOI: https://doi.org/10.1203/00006450-197508000-00060