Abstract
4 children with a pituitary or hypothalamic tumor were studied. 3 of them underwent surgery, post-operatively a growth-spurt followed by normal growth as observed. One of these patients showed an excessive weight gain. The fourth patient in whom the tumor was not removed had a normal growth rate as well. In all 4 patients endocrine evaluation revealed varying degrees of anterior and posterior pituitary insufficiency. Peak CH levels following various stimuli were extremely low in all patients. Prolactin activity in serum as measured by a local pigeon crop assay was elevated in one patient only. In all patients the serum activity of somatomedin was determined by bioassay, serum levels of insulin were measured by RIA during stimulation tests. Our findings suggest that a biological substance other than GH might have induced somatomedin generation in these patients. Supported by Deutsche Forschungsgemeinschaft, SFB 34
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Stahnke, N., Schönberg, D., Steins, P. et al. SUBNORMAL GROWTH HORMONE (GH) LEVELS WITH NORMAL GROWTH. Pediatr Res 9, 674 (1975). https://doi.org/10.1203/00006450-197508000-00059
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DOI: https://doi.org/10.1203/00006450-197508000-00059
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