Abstract
We have measured PRA and PAldo in 13 children with CAH (aged 1 wk-15 yrs) at the time of diagnosis or during salt-losing episodes. As might be expected, very high levels of PRA were found (log mean 20,000pgAI/ml/hr) compared to values of PAldo within the normal range (log mean 12.6ng/100 ml). A further 10 patients (aged 6–18 yrs) who had a history of salt-loss but were clinically well on treatment with corticosteroids but not mineralocorticoids, were also found to have elevated levels of PRA (log mean 3420pgAI/ml/hr) but normal PAldo (log mean 7.9ng/100ml). Of 5 other treated patients (aged 12–18yrs) without previous salt loss, 3 had elevated PRA (1097–10, 632pgAI/ml/hr) and PAldo was again normal (9,8–13.Ing/100 ml). These results suggest that, 1) there is a wide spectrum of salt loss in patients with CAH and, 2) that estimations of PRA may be of some value in ascertaining which patients show persistent salt loss and thus may reauire longterm treatment with mineralocorticoids.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Dillon, M., Grant, D., Levinsky, R. et al. PLASMA RENIN ACTIVITY (PRA) AND ALDOSTERONE CONCENTRATION (PAldo) IN CONGENITAL ADRENAL HYPERPLASIA (CAH) DUE TO 21-HYDROXYLASE DEFICIENCY. Pediatr Res 9, 668 (1975). https://doi.org/10.1203/00006450-197508000-00024
Issue Date:
DOI: https://doi.org/10.1203/00006450-197508000-00024