Abstract
Clearance studies were performed in children with no tubular disease ( I ) with vitamin D resistant rickets ( II ) with hypoparathyroidIsm ( III ) and with vitamin D deficiency rickets (IV). The urinary excretion rate ( UAAV ), clearance ( CAA ) and percentage tubular reabsorption ( CAA ) of 15 free amino acids were calculated before and after an acute intravenous injection of PTH. The following results were obtained: in group I-III there was no significant change in UAAV, CAA, and %TAA after PTH injection. In contrary there was a marked increase in UAAV ( 9.9 to 13.9 nmol/min/1,73 m2) In CAA ( 5.3 to 7.4 ml/min/1.73 m2) and a decrease in %TAA ( 96.7 to 92.9% ) in the group of vitamin D deficiency rickets. These results indicate, that PTH obviously exerts a measurable influence on the tubular reabsorption of amino acids only in vitamin D deficiency.
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Brandis, M., Brodehl, J., Jäkel, A. et al. Influence of parathormone on renal transport of amino acids in children. Pediatr Res 8, 894 (1974). https://doi.org/10.1203/00006450-197411000-00010
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DOI: https://doi.org/10.1203/00006450-197411000-00010