Abstract
In 9 children with vitamin-D-resistant rickets ( VDRR ) urinary phosphate excretion ( UpV ), phosphate clearance ( Cp ) and tubular reabsorption ( Tp ) were measured before and during intravenous phosphate loading. The children with VDRR exhibited significantly lower values for Tp, Tp/CIn and Tmp, while the rate of endogenous phosphate excretion was not higher than in age matched controls. In 5 of these children the effect of 200 I.U. PTH ( Parathormone Lilly ) on UpV, Cp, and Tmp was investigated. PTH has no significant effect on the tubular phosphate reabsorptlon under these conditions. Cyclic AMP, a presumable transmitter of PTH-medlated phosphate-transport, was significantly increased after PTH-injection in all children with VDRR. These results indicate, that in Vitamin D resistant rickets the PTH-sensible component of tubular phosphate transport system is disturbed.
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Krohn, H., Brodehl, J. & Schwabe, U. Renal handllng of phosphate in vitamin D resistant rickets. Pediatr Res 8, 893 (1974). https://doi.org/10.1203/00006450-197411000-00009
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DOI: https://doi.org/10.1203/00006450-197411000-00009