Abstract
18 infants were studied during natural sleep with continuous polygraph recording of ventilation(VE) by nasal pneumotachygraph,end tidal PCO2 (PACO2), EEG, EKG and oculogram (EOG). Sleep state was scored by patterns of EEC, EOG and respiration (and confirmed by observation). VE, f, VT, PACO2 and ventilatory responses to 100% O2 and to 5% CO2 in air were determined in quiet (mean=62 min) and REM (33 min) periods.
12 infants (gest.age 49.2 wk) with unexplained cyanotic spells requiring resuscitation had quiet sleep apnea > 10 sec(2/Hr) and episodes of VE < 50% mean (5 min/Hr);they had REM sleep apnea >10 sec. (1.3/Hr) and VE < 50% mean (3.4 min/Hr). Fall in VE was due to fall in VT to < 3ml/Kg. 6 unaffected infants (gest.age 47.3) had neither > 10 sec apnea nor fall in VE. The steady state response to CO2 was less (30.6 ml/min/Kg/mm Hg) in affected compared to unaffected (39.5) infants in quiet sleep and 26.0 compared to 34.4 in REM sleep.
Infants with unexplained cyanotic spells demonstrated prolonged apnea and depressed VE with abnormal CO2 response in quiet and REM sleep suggesting inadequate integration of respiratory control mechanisms.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Shannon, D., Fagenholz, S. & O'Connell, K. INFANT SLEEP VENTILATION. Pediatr Res 8, 470 (1974). https://doi.org/10.1203/00006450-197404000-00781
Issue Date:
DOI: https://doi.org/10.1203/00006450-197404000-00781