Abstract
The purpose of this study was to establish normal CH50 levels in healthy infants and children, and to compare them with CH50 levels in a population of hospitalized children (HC), and children with acute, poststreptococcal, merabrano-proliferative and Lupus glomerulonephritis (GN). A modification of Kabat and Mayer's method was used; serum was examined fresh or within 2 weeks of quick freezing and storage at -70°C.
In normal children, no correlation was found between CH50 levels and age, sex or race. Mean CH50 titers were similar in normal and hospitalized children, but statistically significantly different from the mean titer in children with GN (p > .001). In screening children with illnesses other than GN, the CH50 test has limited diagnostic value.
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Norman, M., Taylor, A., Nilsson, U. et al. SERUM TOTAL HEMOLYTIC COMPLEMENT (CH50) LEVELS IN NORMAL INFANTS AND CHILDREN. Pediatr Res 8, 459 (1974). https://doi.org/10.1203/00006450-197404000-00714
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DOI: https://doi.org/10.1203/00006450-197404000-00714