Abstract
A family has been evaluated in which the observation of depigmented lesions of the skin constituted the major clue for establishing the diagnosis of incontinentia pigmenti (IP) in the otherwise unaffected mother of the proband. Such lesions are not commonly appreciated as manifestations of IP. They usually form streaked, hypomelanotic macules in the calves but may be found in other areas as well. Their presence in adult relatives of children with IP may provide the only clue of the inherited character of the disease, as in this family. Hence, a search for such lesions is important prior to genetic counseling of these families.
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Wiley, H., Frias, J. & Ayoub, E. DEPIGMENTED LESIONS IN INCONTINENTIA PIGMENTI: A USEFUL DIAGNOSTIC SIGN. Pediatr Res 8, 442 (1974). https://doi.org/10.1203/00006450-197404000-00614
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DOI: https://doi.org/10.1203/00006450-197404000-00614
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