Abstract
To investigate the maternal-fetal transfer of Cefazolin, (CEZ), a new antibiotic, and its distribution in the fetus, a single 14 mg/kg I.M. dose was administered to 41 gravidas (18-lst trimester, 23-2nd trimester) ¼ to 68½ hours prior to therapeutic abortion and sterilization by hysterectomy. CEZ concentration was assayed microbiologically in maternal serum, myometrium, placenta, fetal tissues (brain, lung, liver and kidney) and fetal fluids (amniotic, CSF, urine and serum). Maternal serum half-life of CEZ was 2.2 hours with a peak serum concentration of 63 ug/ml at To. Half-life and maximum CEZ concentrations were 3.2 hours and 0.16 ug/ml for placenta, 3.9 hours and 7.5 ug/ml for cord blood, and 9.4 hours and 0.8 ug/ml for amniotic fluid. CEZ was not detected in fetal CSF, brain, kidney, lung or liver. CEZ was minimally (< 1 ug/ml) detected in fetal urine from 2 to 12 hours. Only three myometrial samples between ¼ and 1 3/4 hours had minimal CEZ concentrations. There were no differences in CEZ concentrations noted in any tissues or fluids with increasing weeks' gestation.
No accumulation of CEZ was demonstrated in the fetus. Fetal serum concentrations were 5 to 10% of the maternal serum and in the MIC range of susceptible organisms.
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Bernard, B., Barton, L., Abate, M. et al. MATERNAL-FETAL TRANSFER OF CEFAZOLIN. Pediatr Res 8, 422 (1974). https://doi.org/10.1203/00006450-197404000-00490
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DOI: https://doi.org/10.1203/00006450-197404000-00490