Abstract
The frequencies of 24 hlstocompatibility antigens (HL-A) were examined in 26 patients with juvenile rheumatoid arthritis (JRA). Specificity W27 was noted in 42 per cent (11 patients) compared to 6 per cent of 267 normal controls (p < 0.0000). The group with W27 had more males (6 out of 11 versus 3 of 15), an earlier age of onset (4.5 versus 8.4 years p < .02) and absence of rheumatoid factor and antinuclear antibody. Distribution by type of onset of disease did not differ between those with or without W27. No patient had evidence of sacro-iliac joint disease.
The presence of W27 in JRA. suggests an environmental and/ or genetic link between this disease, Reiter's disease and ankylosing spondylitis.
Follow-up of JRA patients with W27 could provide a clue to the etiology of a variety of rheumatic disorders and could help in the overall treatment and perhaps their prevention.
Article PDF
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Rachelefsky, G., Terasaki, P., Katz, R. et al. INCREASED INCIDENCE OF W27 IN JUVENILE RHEUMATOID ARTHRITIS. Pediatr Res 8, 417 (1974). https://doi.org/10.1203/00006450-197404000-00465
Issue Date:
DOI: https://doi.org/10.1203/00006450-197404000-00465