Abstract
Children with T cell lymphoblastic lymphoma (TLL)(J. Kaplan, et al. Cancer Res., 1974, in press) frequently present with MM and subsequently develop rapidly progressive leukemia. Four such children died between 3 and 14 months after onset of bone marrow involvement. Since childhood leukemia presenting with MM (ALL+MM) may actually be a generalized form of TLL, a retrospective study was conducted to compare the clinical course of 9 such patients and 74 children with typical ALL. Therapy of both groups was similar. The % of surviving patients and % in complete remission in both groups at 6, 12 and 18 months after diagnosis are shown in the following table:
In comparison to other children with ALL, those presenting with MM had more frequent early relapses and shortened survival. These findings indicate that, with a representative mode of ALL therapy, children with ALL+MM do poorly when compared to children with typical ALL. This difference may be related to a T cell origin of tumor cells in ALL+MM. Therapeutic regimens different from those currently used for ALL may be indicated for children with ALL+MM.
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Ravindranath, Y., Kaplan, J. & Zuelzer, W. SIGNIFICANCE OF MEDIASTINAL MASS (MM) IN ACUTE LYMPHOBLASTIC LEUKEMIA (ALL). Pediatr Res 8, 408 (1974). https://doi.org/10.1203/00006450-197404000-00406
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DOI: https://doi.org/10.1203/00006450-197404000-00406