Abstract
An 11 year old girl with aplastic anemia of unknown etiology was transplanted with MLC and HLA identical sibling marrow following 4 doses of Cyclophosphamide (CY) 50 mg/kg. She had received multiple blood transfusions before transplantation (TP). Three weeks following TP the marrow was repopulating, but 4 weeks later the marrow was again aplastic. Immunosuppression with Procarbazine, anti-thymocyte globulin, and a repeat course of CY were given followed by a second TP from the same donor. A take of donor marrow cells now occurred and has persisted to the present (140 days after TP). No evidence of graftversus-host disease was seen; PHA responsive peripheral blood lymphocytes have remained predominantly of host type. The patient has remained in excellent clinical health. Her B cell function is normalizing, but her T cell function is as yet depressed.
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Meuwissen, H., Moore, E., Strauss, H. et al. SUCCESSFUL MARROW RE-TRANSPLANTATION FOLLOWING FAILURE OF FIRST TRANSPLANT FOR APLASTIC ANEMIA. Pediatr Res 8, 406 (1974). https://doi.org/10.1203/00006450-197404000-00395
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DOI: https://doi.org/10.1203/00006450-197404000-00395