Abstract
Whole blood (WB) and plasma (P1) histamine and P1 cortisol were determined in 20 cases of acute leukemia at diagnosis, after induction therapy and during maintenance. Twelve cases of I.T.P., 7 cases of Henoch-Schönlein purpura and 8 cases of aplastic anemia were also studied and results compared to 50 normal controls.
-A significant reduction of WB and P1 histamine was found at diagnosis in acute leukemia and aplastic anemia. The depletion level, particularly in WB, was more marked in aplastic anemia cases. After onset of remission in acute leukemia, the histamine levels of WB and P1 became abnormally high; at maintenance P1 histamine returned to normal levels, while WB histamine remained high.
-In I.T.P. no significant change in histamine levels was found.
-In Henoch-Schönlein purpura the histamine levels were significantly elevated.
-The P1 cortisol levels were significantly higher than normal in acute leukemia cases, decreased but still elevated in remission and during maintenance. They were significantly higher than normal in I.T.P., Henoch-Schönlein purpura and aplastic anemia.
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Khalifa, A., Zuelzer, W., Lusher, J. et al. HISTAMINE AND CORTISOL LEVELS IN SOME HEMATOLOGICAL DISORDERS. Pediatr Res 8, 403 (1974). https://doi.org/10.1203/00006450-197404000-00379
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DOI: https://doi.org/10.1203/00006450-197404000-00379