Abstract
111Indium labelled Bleomycin (IB) is a new radio-pharmaceutical which localizes in a wide variety of animal and human tumors. In this study of 13 children with malignant solid tumors 20 total body scans were performed. The scans were obtained 48 hours after intravenous administration of less than 2 millicuries of IB (Bleomycin less than 0.4 mg/dose). In 3 patients with lymphoma, 5 with neuroblastoma, 2 with rhabdomyosarcoma, 1 with leiomyosarcoma, and 2 with malignant teratoma an excellent correlation was observed between abnormal accumulations of IB and known sites of tumor involvement. The most precise imaging of tumor was for lymph node and soft tissue sites of disease, both above and below the diaphragm. At 48 hours IB was normally observed in liver, kidneys, and bone marrow. Hepatic and osseous involvement was difficult to assess, necessitating other specific scans for evaluation. The data suggest that tumor scanning with 111Indium-Bleomycin is an extremely valuable technique for staging and serial evaluation of children with solid tumors.
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Johnson, H., Corrigan, J., O'Mara, R. et al. INDIUM-BLEOMYCIN SCANNING IN PEDIATRIC MALIGNANT SOLID TUMORS. Pediatr Res 8, 402 (1974). https://doi.org/10.1203/00006450-197404000-00374
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DOI: https://doi.org/10.1203/00006450-197404000-00374