Abstract
Over a one year period, 44 bilirubin binding assays were requested on premature and sick newborns. Total serum bilirubins ranged from 7.6 to 25.4 mg% with reserve bilirubin binding capacities ranging from −4 to 18 mg%. The saturation points ranged from 7.6 to 29.4 mg%. 85% had a saturation point greater than 15 mg%, with 50% greater than 20 mg%. Only a single baby had a saturation point less than 10 mg%. None of the babies with negative binding capacities showed clinical evidence of kernicterus. Several babies placed on phototherapy showed no change in their saturation points when assayed before, during, and following treatment, thus indicating that the breakdown products of bilirubin or other effects of phototherapy do not interfere with bilirubin binding to albumin.
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Dupont, C., Allen, J. & Sarkozy, E. EXPERIENCE WITH THE SEPHADEX GEL FILTRATION ASSAY FOR RESERVE BILIRUBIN BINDING CAPACITY IN NEWBORNS. Pediatr Res 8, 399 (1974). https://doi.org/10.1203/00006450-197404000-00356
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DOI: https://doi.org/10.1203/00006450-197404000-00356