Abstract
Six percent of infants with severe acute diarrhea follow a relapsing course associated with the development of glucose intolerance and malnutrition. The basis for diagnosis of AMI is the occurrence of dehydrating diarrhea with acid stools (glucose positive) when fed 5% glucose electrolyte mix. The duodenal microflora was studied in four of these children to determine whether an overgrowth of anaerobic bacterial flora was present simulating the “blind loop” syndrome. Nine patients with acute diarrhea (A.D.) and 10 with chronic nonspecific diarrhea (CND) were also studied by the same techniques. The duodenum was intubated and samples obtained for aerobic and anaerobic culture (roller tube technique). Only one of four patients with AMI had strict anaerobic flora present in duodenum (105 clostridium sphenoides). Seven of the children with AD had anaerobes present at concentrations > 104. In CND none had anaerobes < 105. No colifonns were present in the duodenum of subjects with AMI, but were present in 90% of the other infants with diarrhea. The results exclude the primary role of anaerobic bacterial overgrowth in the pathogenesis of AMI. Work supported by Mead Johnson Laboratories, David Underwood Trust, NASA Contract 90059 and USPH RR-00188.
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Rodriguez, J., Mastromarino, A., Ordoñez, J. et al. ROLE OF ALTERED ANAEROBIC MICROFLORA IN ACQUIRED MONOSACCHARIDE INTOLERANCE (AMI). Pediatr Res 8, 385 (1974). https://doi.org/10.1203/00006450-197404000-00270
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DOI: https://doi.org/10.1203/00006450-197404000-00270