Abstract
18 subjects, 5-20 yrs, received LRF to determine if the responses of serum LH & FSH might be useful in specific situations. The subjects who received LRF, 50-100 ugs IV, had hypopituitarism, intrasellar mucocoele (A); constitutional delay, normal female (B); delayed puberty & anosmia, anorchia & encephalocoele (C); obesity (D); anorexia nervosa (E) & gonadal dysgenesis (F).
A prepubertal hypopit had FSH 0.7 mIU/ml (peak 4.5); LH was basal 16.0 (peak 31.7). B had no LH, FSH abnormality. LH did not rise in anorchia; C had no FSH peaks. D had no peaks but basal LH, FSH were higher than expected for age. E had low LH & no rise in FSH (N) in one. F had elevated LH, FSH. The LRF test is useful for evaluation of suspected htypothalamic-pituitary disorders.
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Kirkland, R., Tenore, A., Vaidya, V. et al. PATTERNS OF LH & FSH RELEASE STIMULATED BY LUTEINIZING HORMONE RELEASING FACTOR (LRF) IN 18 CHILDREN. Pediatr Res 8, 370 (1974). https://doi.org/10.1203/00006450-197404000-00182
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DOI: https://doi.org/10.1203/00006450-197404000-00182