Abstract
Extract: Functional and morphologic studies of fibrin formation in the presence of a variety of cancer chemotherapeutic agents in vitro showed that some of these drugs cause fibrinolysis, inactivation of fibrin-stabilizing factor (FSF), or a combination of both. The drugs with most potent activity are 5-[3,3-bis(2-chloroethyl)-1-triazeno]imidazole-4-carboxamide (TIC mustard), 5-fluorouracil, nitrogen mustard, adriamycin, and daunomycin. These changes were dose related.
Speculation: Interference with fibrin formation by anticoagulation has been associated with reduced implantability of tumor emboli in experimental systems. This study presents evidence that some cancer chemotherapeutic agents have chemical properties of an anticoagulant nature. In addition to any influence on cell multiplication, high pulse doses of adjuvant chemotherapy at the time of tumor manipulation such as surgery may interfere with fibrin formation around tumor emboli and discourage metastatic implantation.
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Komp, D., Lyles, R., Boyd, T. et al. The Effect of Cancer Chemotherapeutic Agents on Fibrin Formation and Stabilization in Vitro. Pediatr Res 8, 75–81 (1974). https://doi.org/10.1203/00006450-197402000-00002
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DOI: https://doi.org/10.1203/00006450-197402000-00002